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KMID : 0613820120220070958
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Journal of Life Science
2012 Volume.22 No. 7 p.958 ~ p.963
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Effect of Artemisia capillaris Extracts on Antioxidant Activity and Allergic Dermatitis
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Kim Jong-Myeung
Shin Yong-Kyu
Kim Byung-Oh
Kim Jong-Kuk
Lee Sang-Han
Kim Young-Sup
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Abstract
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The antioxidant activities of 6 solvent extracts of Artemisia capillaris were evaluated in a dintroflurobenzen (DNFB)-induced allergic mouse model. In vitro antioxidant activities were determined using DPPH and the FRAP test. Methanol (DPPH: 85.87%, FRAP: 1.772) and dH₂O (DPPH: 60.69%, FRAP: 3.185) extracts showed the highest antioxidant activities compared with other solvents (ethyl acetate 41.81%, 0.407, hexane 8.37%, 0.328, etc.). In addition, we tested atopic dermatitis (AD)-like skin lesions in mice treated with DNFB. The methanol extract of A. capillaris on the AD-like skin lesions in DNFB-induced atopy inhibited ear thickness increases (47%) and the skin lesions (45%) compared with a positive control (methanol). The results suggest that they have potential as natural antioxidants and allergy-improving substances and that they may be valuable materials in the functional food or cosmeceutical industry.
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KEYWORD
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Artemisia capillaris, antioxidant, allergy, dintroflurobenzen (DNFB)
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